Improved persistence and adherence to diuretic fixed-dose combination therapy compared to diuretic monotherapy

Improved persistence and adherence to diuretic fixed-dose combination therapy compared to diuretic monotherapy

BACKGROUND Diuretics are recommended as initial treatment for hypertension. Several studies have suggested suboptimal persistence and adherence to thiazide diuretic monotherapy; this study compared patient persistence and adherence with hydrochlorothiazide (HCTZ) monotherapy to fixed-dose combinations containing HCTZ. METHODS Patients with at least one prescription claim during 2001 to 2003 f...

Author ' s response to reviews Title : Improved persistence and adherence to diuretic fixed - dose combination therapy compared to diuretic monotherapy

Rational approaches to the treatment of hypertension: drug therapy—monotherapy, combination, or fixed-dose combination?

Blood pressure (BP) control is inadequate worldwide. Many clinical trials suggest that BP is not satisfactorily controlled using monotherapy in most patients. Free drug or fixed-dose combinations are other therapeutic options. The advantages and disadvantages for different treatment approaches are discussed in this review.

Adherence to oral antidiabetic therapy in a managed care organization: a comparison of monotherapy, combination therapy, and fixed-dose combination therapy.

BACKGROUND Although medication adherence is one of the most important aspects of the management of diabetes mellitus, low rates of adherence have been documented. OBJECTIVE This study sought to examine medication adherence among patients with diabetes mellitus in a managed care organization who were receiving antidiabetic monotherapy (metformin or glyburide), combination therapy (metformin an...

Diuretic therapy and diuretic resistance in cardiac failure.

s 40 venous capacitance within a few minutes before any with oedema is defined as a clinical state where the braking phenomenon occurs before the therapeutic measurable increase in urinary output can be seen [1,2]. This rapid haemodynamic improvement is goal is reached. thought to be due to the release of vasodilatory prostaglandins [3]. However, in a study in patients with severe oedema, i.v. ...